メラトニンサプリメントさぷりめんと長期ちょうき使用しようと心不全しんふぜんリスクりすく上昇じょうしょうの関連性かんれんせい――最新さいしん研究けんきゅうが示唆しさする課題かだいと今後こんごの展望てんぼう

In recent years, new research has announced that long-term use of melatonin supplements, which are widely used as sleep aids, may be associated with an increased risk of heart failure.

However, in this study, it is not necessary for people using melatonin to immediately stop its use.

According to a large-scale electronic medical record study, adults suffering from chronic insomnia who have used melatonin for over a year have about a 90% higher risk of developing heart failure over the next five years compared to those with similar health conditions who do not use melatonin.

Furthermore, the group that used melatonin had more than three times higher risk of hospitalization due to heart failure and nearly double the risk of all-cause mortality.

However, experts believe that it is still too early to draw conclusions about the dangers of melatonin at this point.

There are significant design limitations in this study, and it cannot prove causality.

Furthermore, this result is also inconsistent with previous studies suggesting that melatonin has beneficial effects on the cardiovascular system.

This paper has not yet been peer-reviewed or published in an academic journal.

Dr. Nadi, the resident chief at the State University of New York SUNY and the primary author, stated, Melatonin supplements are considered a natural and safe option by many people, but it is surprising that, even after adjusting for various factors, there is a consistent and significant increase in adverse health effects.

However, he also emphasized that “while this case raises concerns about the safety of melatonin supplements, a direct causal relationship has not yet been proven,” and called for further research in the future.

Melatonin is a hormone that is naturally produced in the brain. When it gets dark, it is secreted by the pineal gland and plays a role in promoting sleep.

Melatonin contained in supplements may be derived from animals or may be chemically synthesized.

In the United States, melatonin is distributed as a supplement, so it is not subject to the strict regulations that apply to FDA-approved medications.

Therefore, it cannot be ruled out that the product may contain active ingredients exceeding the labeled amount or harmful additives.

Chronic insomnia is defined as a condition in which it takes more than 30 minutes to fall asleep or get back to sleep, occurring at least three times a week for more than three months, and it is estimated to affect about 10% of the world’s population.

Insomnia can negatively affect memory, daytime energy, mood, thinking ability, concentration, and even social life.

Doctors determine whether the cause of insomnia is due to illness or stress, and then select the most appropriate treatment method, such as adjusting sleep habits, cognitive behavioral therapy, or medication.

Currently, there is not enough data on the long-term safety of melatonin for the cardiovascular system.

In this study, we analyzed the health records of more than 130,000 adults registered in the international large-scale database TriNetX Global Research Network.

The average age of the study participants was approximately 55 years, and 61.4% of them were women.

People who have been using melatonin for more than a year are classified as the melatonin group, while those who have never used it before are classified as the non-melatonin group. However, since the patients include those from countries where melatonin is a prescription drug such as the UK and those from countries where it can be purchased without a prescription such as the US, there is a possibility that the control group also includes people who use melatonin without a prescription.

Furthermore, the lack of detailed information regarding the severity of insomnia and mental health status may also affect the reliability of the research results.

It has been shown that insomnia itself is associated with an increased risk of heart attacks and strokes, and it is also known that circadian rhythm disorders and lack of sleep raise the risk of developing cardiovascular diseases.

Furthermore, the lack of information regarding the dosage is also an important limitation.

Supplement industry groups state, If used in low doses and for a short period of time, its safety for healthy adults has been confirmed.

Melatonin also has antioxidant properties and is thought to protect DNA from oxidative stress in the body.

In several previous studies, melatonin has been reported to improve the quality of life and cardiac function in patients with heart failure, which contradicts the results of the present study.

When using sleep aids, it is important to consult a doctor, receive a diagnosis, and choose an appropriate treatment method.

Experts advise against the long-term use of melatonin unless there are legitimate instructions to do so.

To maintain healthy sleep hygiene, it is recommended to avoid exposure to light and screens, as well as eating and drinking before bedtime, and to optimize the bedroom environment.